Piperidino-pyrimidine derivatives for the treatment of viral infections

A compound of formula (I)

• or a pharmaceutically acceptable salt, tautomer(s), solvate or polymorph thereof, wherein
• A is selected from the group consisting of CH2, NCOR2, CHR3 and CR3R3 in any stereo chemical configuration,
• B is selected from the group consisting of CH2, NCOR4, CHR3 and CR3R3 in any stereo chemical configuration,
• with the proviso that when A is NCOR2 then B is not NCOR4 and with the proviso that A and B are not both selected from CH2, CHR3 or CR3R3,
• X is selected from CH2 or CHR5 in any stereo chemical configuration,
• R1 is selected from C1-8alkyl optionally substituted with one or more of the following:
• C1-6alkyl, C3-7cycloalkyl, hydroxyl, hydroxyalkyl, amino, nitrile, alkoxy, alkoxy-(C1-4)alkyl, carboxylic acid, carboxylic ester, carbamate or sulfone,
• R2 is selected from substituted and unsubstituted C1-6alkyl, C3-7cycloalkyl, heterocycle, aryl, heteroaryl, heteroarylalkyl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C1-6alkyl, di-(C1-6)alkylamino, C1-6alkylamino, C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile,
• R3 is selected from hydrogen, substituted and unsubstituted C1-6alkyl, alkoxy, alkoxy-(C1-4)alkyl, C3-7cycloalkyl, C4-7heterocycle, aromatic, bicyclic heterocycle, arylalkyl, heteroaryl, heteroarylalkyl each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C1-6alkyl, di-(C1-6)alkylamino, C1-6alkylamino, C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile,
• R4 is selected from substituted or unsubstituted C1-7alkyl, alkoxy, alkoxy-(C1-4)alkyl, aryl or C3-7cycloalkyl each of which is optionally substituted by heterocycle, nitrile, heteroarylalkyl or heteroaryl and wherein
• R5 is selected from aromatic, bicyclic heterocycle, aryl, heteroaryl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C1-6alkyl, di-(C1-6)alkylamino, C1-6alkylamino, C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, carboxylic acid, carboxylic ester, carboxylic amide, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile.