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US 2014/0350023 A1Published application
Amorphous form of sitagliptin salts
AssigneeRanbaxy Laboratories Limited
InventorsSuresh Babu Jayachandra, Jigar Bhaskarbhai Shah, Chiguru Sailu, Sandeep Thakaji Kanawade
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Abstract
The present invention claims amorphous solid state forms of sitagliptin salts, processes for their preparation, and pharmaceutical compositions thereof. As salt forming anions are claimed: The maleate, fumarate, besylate, mesylate and succinate.
Claims24
Amorphous form of a sitagliptin compound of Formula I
- wherein HA is selected from the group consisting of maleic acid, fumaric acid, benzenesulfonic acid, methanesulfonic acid, and succinic acid.
A process for the preparation of an amorphous form of the compound of Formula I
- wherein HA is selected from the group consisting of maleic acid, fumaric acid, benzenesulfonic acid, methanesulfonic acid, and succinic acid, the process comprising:
- a. treating sitagliptin with HA wherein HA is selected from the group consisting of maleic acid, fumaric acid, benzenesulfonic acid, methanesulfonic acid, and succinic acid;
- and
- b. isolating an amorphous form of the compound of Formula I.
1 more element
(canceled)
Dependencies are inferred from the claim text.