Pyridine and pyrimidine based compounds as wnt signaling pathway inhibitors for the treatment of cancer

A compound of the formula (I):

• wherein
• X and Y are each independently CH, C(R4) or N;
• W is C(R4);
• Z is C(R6) or N;
• R1 and R2 are each independently hydrogen or C1-6 alkyl;
• or R1 and R2 taken together with the carbon atom to which they are attached may form a 5- or 6-membered carbocycle or heterocycle, either of which is optionally substituted with 1, 2, 3, 4 or 5 Ra;
• R3 and R4 are each independently a group selected from C1-6 alkyl, C1-6 alkoxy, carbocyclyl and heterocyclyl, any of which is optionally substituted with 1, 2, 3, 4 or 5 Ra;
• when Z is N, R5 is R7, —C(O)R7, —C(O)OR7—, —S(O)lR7, —C(O)N(R7)R8, —C(S)N(R7)R8—, —S(O)lN(R7)R8 or heterocyclyl optionally substituted with 1, 2, 3, 4 or 5 Ra;
• when Z is C(R6), R5 is H, CN, C(O)OH, —C(O)R7, —C(O)OR7—, —S(O)lR7, —N(R6)R7, —C(O)N(R7)R8, —C(S)N(R7)R8—, —S(O)lN(R7)R8, —N(R7)C(O)R8, —N(R7)S(O)lR8 or a C1-6 alkyl or heterocyclyl group which is optionally substituted with 1, 2, 3, 4 or 5 Ra;
• R6 is hydrogen, C1-6 alkyl, C1-6 alkoxy, —OH, R5, (CH2)mR5 or —N(R7)R8;
• R7 and R8 are each independently hydrogen or a group selected from C1-6 alkyl optionally containing 1, 2 or 3 heteroatoms selected from N, O and S, carbocyclyl and heterocyclyl, any of which is optionally substituted with 1, 2, 3, 4 or 5 Ra;
• or R7 and R8 may be linked so that, together with the atoms to which they are attached, they form a 5- or 6-membered heterocycle which is optionally substituted with 1, 2, 3, 4 or 5 Ra;
• each Ra is independently selected from halogen, trifluoromethyl, cyano, oxo, nitro, —ORb, —C(O)Rb, —C(O)ORb, —OC(O)Rb, —S(O)lRb, —N(Rb)Rc, —N(Rb)C(O)Rc, —C(O)N(Rb)Rc, —S(O)lN(Rb)Rc and Rd;
• Rb and Rc are each independently hydrogen or Rd;
• Rd is selected from hydrocarbyl (e.g. C1-6alkyl), carbocyclyl, carbocyclyl-C1-6alkyl, and heterocyclyl, each of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C1-6 alkyl, C1-6 alkoxy;
• l is 0, 1 or 2;
• and
• m and n are each independently 1, 2 or 3;
• or a pharmaceutically acceptable salt or N-oxide thereof.