D2 antagonists, methods of synthesis and methods of use

A compound of formula:

• I
• or a pharmaceutically acceptable salt thereof, or isomer thereof, wherein
• R1 is chosen from the group consisting of
• (2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)(C2-C4alkyl) optionally substituted at the 3 position with cyclopropyl or at the 6 position with chlorine,
• (2-oxobenzo[d]oxazol-3(2H)-yl)(C2-C4alkyl),
• (2-oxobenzo[d]thiazol-3(2H)-yl)(C2-C4alkyl),
• (2-oxoindolin-1-yl)(C2-C4alkyl) optionally substituted at the 3-position with one or two components chosen from methyl or fluoro,
• (3-spirocyclopropane-(2-oxoindolin-1-yl))(C2-C4alkyl),
• (2-oxoindolin-3-yl))(C2-C4alkyl),
• bis(4-fluorophenyl)methyl-(C1-C6alkyl),
• (1H-benzo[d][1,2,3]triazol-1-yl)(C2-C4alkyl),
• 2,3-dihydrobenzo[b][1,4]dioxine-2-(C2-C4alkyl),
• 1-(thiophen-2-yl)-1-oxo-(C1-C6alkyl),
• 3-oxo-2H-benzo[b][1,4]oxazin-4-yl))(C2-C4alkyl),
• (2-(cycloalkyl)-1H-benzo[d]imidazol-1-yl)(C2-C4alkyl),
• ((3-((C1-C6alkyl)carbonyloxy(methyl))-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl))(C2-C4 alkyl),
• ((3-(methoxycarbonylethyl)-2-oxo-2,3-dihydro-1H-benzo[c/]imidazol-1-yl))(C2-C4 alkyl),
• ((2-(t-butoxycarbonyl)-2,3-dihydro-1H-benzo[c/]imidazol-1-yl))(C2-C4 alkyl),
• 1H-indazol-3-yl(C2-C4 alkyl),
• (1-(indolin-1-yl)-1-oxo)(C2-C4alkyl),
• ((3-(C1-C6alkyl)oxycarbonyl(C1-C6alkyl))-1H-indol-1-yl)(C2-C4alkyl), or
• (2-(C1-C6alkyl)oxycarbonyl-1H-indol-1-yl)(C2-C4alkyl)
• R2 is phenyl optionally para-substituted with chloro, fluoro or methoxy, linear or branched C2-C6 alkyl, cycloalkyl of three to seven carbon atoms optionally substituted with one to six halogens;
• R3 is
• wherein n is 3-5,
• and
• R10 is H or alkyl of one to six carbons.