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US 2014/0350003 A1Published application
Metalloenzyme inhibitor compounds
AssigneeViamet Pharmaceuticals, Inc.
InventorsWilliam J. Hoekstra, Stephen W. Rafferty, Christopher M. Yates, Robert J. Schotzinger, Michael R. Loso, Michael T. Sullenberger, Gary D. Gustafson
Life of this patent
Estimating the term…
Abstract
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Claims18
1-14. (canceled)
A composition comprising a compound of Formula I, or salt thereof, and an agriculturally acceptable carrier;
- wherein MBG is optionally substituted tetrazolyl, optionally substituted triazolyl, optionally substituted oxazolyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted pyrazolyl;
- R1 is H, halo, alkyl, or haloalkyl;
- R2 is H, halo, alkyl, or haloalkyl:
- R3 is independently H, alkyl, alkenyl, cycloalkyl, heteroaryl, hydroxyalkyl, cyano, haloalkyl, halo, —C(O)phenyl, —CH(OH)(aryl), —CH(aryl), —CH2(heteroaryl), —CF(aryl), —CF2(heteroaryl), —CH2O(aryl), —CH2O(heteroaryl), —CH2S(O)X(aryl), and cyclic amino, wherein each of the alkyl, alkenyl, cycloalkyl, heteroaryl, hydroxyalkyl, haloalkyl, —C(O)phenyl, —CH(OH)(aryl), —CH2(aryl), —CH2(heteroaryl), —CF2(aryl), CF2(heteroaryl), —CH2O(aryl), —CH2O(heteroaryl), —CH2S(O)x(aryl), and cyclic amino may be optionally substituted with 1, 2 or 3 independent R7;
- R4 is aryl, heteroaryl, or cycloalkyl, each optionally substituted with 0, 1, 2 or 3 independent R8;
- R5 is independently H, halo, alkyl, alkoxy, cyano, haloalkyl, haloalkoxy, halothioalkyl, thioalkyl, SF3, SF6, SCN, SO2R11, cycloalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl;
- R6 is independently H, halo, alkyl, alkoxy, cyano, haloalkyl, haloalkoxy, halothioalkyl, thioalkyl, SF3, SF6, SCN, SO2R11, cycloalkyl, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl;
- each R7 is independently cyano, cycloalkyl, haloalkyl, hydroxy, alkoxy, aryl, aryloxy, heteroaryloxy, halo, haloalkoxy, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl;
- each R8 is independently cyano, haloalkyl, hydroxy, alkoxy, halo, or haloalkoxy;
- R9 is H, halo, or haloalkyl;
- R10 is H, alkyl, —Si(R12)3, —P(O)(OH)2, —CH—O—P(O)(OH)2, or —C(O)alkyl optionally substituted with amino;
- R11 is independently alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- R12 is independently alkyl or aryl;
- and
- x is independently 0, 1, or 2.
12 more elements
16-20. (canceled)
Dependencies are inferred from the claim text.