Genetic Markers for Optimizing Treatment for Schizophrenia
AssigneeSuregene, LLC
InventorsMark David Brennan, Timothy Lynn Ramsey
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Abstract
This document provides methods and materials related to genetic markers for predicting response to a treatment for schizophrenia (SZ). For example, methods for using such genetic markers to select optimal treatments are provided.
Claims23
A method of predicting a human patient's likely response to a treatment for schizophrenia (SZ), the method comprising determining the identity of an allele of at least one polymorphism listed in Tables 1-20, wherein the presence of an allele associated with a known response indicates the patient's likely response to the treatment.
A method of selecting a treatment for schizophrenia (SZ) for administration to a human patient, the method comprising:
- determining the identity in the subject of an allele of at least one polymorphism listed in Tables 1-20;
- comparing the identity of the allele in the subject to a reference allele of the same polymorphism, wherein the reference allele is associated with a known response to a treatment;
- and
- selecting a treatment if the allele in the patient is the same as a reference allele that is associated with a positive response to that treatment.
Dependencies are inferred from the claim text.