Methods for treating antipsychotic-induced weight gain
AssigneeAlkermes Pharma Ireland Limited
InventorsDaniel Deaver, Mark Todtenkopf
Life of this patent
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Abstract
The present invention relates to the discovery of a novel opioid modulator effective in reducing pharmacologically induced weight gain associated with atypical antipsychotic use. The present invention provides methods of reducing antipsychotic induced weight gain, methods for suppressing food intake and reducing ghrelin levels induced by atypical antipsychotic medications in a patient.
Claims14
A method of reducing antipsychotic induced weight gain comprising administering to the patient in need of treatment an effective amount of a compound of Formula I;
- wherein, A is chosen from —C(═O)NH2 and —C(═S)NH2;
- R1 and R2 are both hydrogen or taken together R1 and R2 are ═O;
- R3 is chosen from hydrogen, alkyl, alkenyl, aryl, heterocyclyl and hydroxyalkyl;
- R4 is chosen from hydrogen, hydroxy, amino, alkoxy, C1-C20 alkyl and C1-C20 alkyl substituted with hydroxy or carbonyl;
- R5 is selected from hydrogen, hydroxyl, alkoxy and alkyl;
- R6 is chosen from hydrogen, hydroxy, alkoxy and —NR10R11;
- or together, R5 and R6 form a carbonyl or a vinyl substituent;
- R10 and R11 are chosen independently from hydrogen and alkyl and aliphatic;
- and,
- represents a single or double bond.
3-5. (canceled)
11-27. (canceled)
A method of reducing Ghrelin level in the gastrointestinal tract comprising the step of administering a compound of Formula I to a patient in need thereof.
A composition comprising an atypical antipsychotic and a compound of Formula I;
- wherein, A is chosen from —C(═O)NH2 and —C(═S)NH2;
- R1 and R2 are both hydrogen or taken together R1 and R2 are ═O;
- R3 is chosen from hydrogen, alkyl, alkenyl, aryl, heterocyclyl and hydroxyalkyl;
- R4 is chosen from hydrogen, hydroxy, amino, alkoxy, C1-C20 alkyl and C1-C20 alkyl substituted with hydroxy or carbonyl;
- R5 is selected from hydrogen, hydroxyl, alkoxy and alkyl;
- R6 is chosen from hydrogen, hydroxy, alkoxy and —NR10R11;
- or together, R5 and R6 form a carbonyl or a vinyl substituent;
- R10 and R11 are chosen independently from hydrogen and alkyl and aliphatic;
- and
- represents a single or double bond.
Dependencies are inferred from the claim text.