Organonitro thioether compounds and medical uses thereof

A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an organonitro compound of Formula I or II, wherein Formula I is represented by:

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• A1 is N or —C(R5)—;
• A2 is —C(O)— or —(C(R6)2)xC(O)(C(R6)2)x—;
• R1 is C1-C5alkyl;
• R2 and R3 each represent independently for each occurrence hydrogen or C1-C5alkyl;
• or R2 and R3 are taken together with the carbon atom to which they are attached to form a carbocyclic ring;
• R4 is C1-C5alkyl substituted with one X1 group and one X2 group;
• wherein X1 is —N(R7)(R8), —N(R7)C(O)—C1-C5alkyl, —N(R7)C(O)—C3-C7cycloalkyl, —N(R7)C(O)-aryl, —N(R7)C(O)-aralkyl, or —N(R7)C(O)—(C1-C5alkylene)-C(H)[N(R7)(R8)]—CO2R9;
• and X2 is —CO2R10 or —C(O)N(R7)—(C1-C5alkylene)-CO2R10;
• R5 is hydrogen or C1-C5alkyl;
• R6 represents independently for each occurrence C1-C6alkyl, C1-C5haloalkyl, aryl, or aralkyl;
• R7 and R8 each represent independently for each occurrence hydrogen or C1-C5alkyl;
• or R7 and R8 are taken together with the nitrogen atom to which they are attached to form a 3-7 membered heterocyclic ring;
• R9 and R10 each represent independently hydrogen, C1-C5alkyl, C3-C7cycloalkyl, aryl, or aralkyl;
• n, p, and t are independently 1, 2, or 3;
• and
• m and x each represent independently for each occurrence 0, 1, 2, or 3;
• Formula II is represented by:
• or a pharmaceutically acceptable salt or solvate thereof:
• wherein:
• A1 is —N(R5)— or —C(R2)(R3)—;
• A2 is —C(O)— or —(C(R6)2)xC(O)(C(R6)2)x—;
• R1 is C1-C5alkyl or C3-C7cycloalkyl;
• R2 and R3 each represent independently for each occurrence hydrogen or C1-C5alkyl;
• or R2 and R3 are taken together with the carbon atom to which they are attached to form a carbocyclic ring;
• R4 is C1-C5alkyl substituted with one X1 group and one X2 group;
• wherein X1 is —N(R7)(R8), —N(R7)C(O)—C1-C5alkyl, —N(R7)C(O)—C3-C7cycloalkyl, —N(R7)C(O)-aryl, —N(R7)C(O)-aralkyl, or —N(R7)C(O)—(C1-C5alkylene)-C(H)[N(R7)(R8)]—CO2R9;
• and X2 is —CO2R10 or —C(O)N(R7)—(C1-C5 alkylene)-CO2R10;
• R5 is hydrogen or C1-C5alkyl;
• R6 represents independently for each occurrence C1-C5alkyl, C1-C5haloalkyl, aryl, or aralkyl;
• R7 and R8 each represent independently for each occurrence hydrogen or C1-C5alkyl;
• or R7 and R8 are taken together with the nitrogen atom to which they are attached to form a 3-7 membered heterocyclic ring;
• R9 and R10 each represent independently hydrogen, C1-C5alkyl, C3-C7cycloalkyl, aryl, or aralkyl;
• t and v are independently 1, 2, or 3;
• and
• x represents independently for each occurrence 0, 1, 2, or 3.