Epigenetic markers for detection of autism spectrum disorders
AssigneeZymo Research Corporation
InventorsXueguang Sun, Xiyu Jia
Life of this patent
Estimating the term…
Abstract
Methods for determining if a patient has, or is at risk of having, and autism spectrum disorder by detecting epigenetic changes in the genome of the patient. For example, a method can comprise determining the methylation status of one or more genes in a blood sample.
Claims26
A method of analysis comprising determining a methylation status in two or more genes in a patient sample from a patient suspected of having an autism spectrum disorder, the genes selected from the group consisting of CES1, NGDN, HAL, S100A1, OTOF—1, MTBP, MRPL13, HOXB6, KAZN, MORC2, LCK, ZNF248, ANAPC7, SEC1, THOC6, HCFC1R1, ABCE1, ANAPC10, DDX18, CD1D, ALKBH6, S100A13, SPIN3, LALBA, EIF4A1, CENPF, AIRE, ANKRD13C, GHSR, EIF3G, NOLC1, TPX2, BDNF, FAM149B1, ECD, OGG1, KATNAL1, IGFBP5, MRPS15, HIST1H4K, CMYA5, ARMC1, LOC286002, PAIP2, MARCKS, DNAJC25, BLZF1, NME7, C12orf26, CCDC59, MCRS1, RBM4B, MIR548H4, TEKT1, TMEM184C, TTC22, FAM164A, PACRGL, CCDC58, TMEM126B, BLCAP, LOC100131564, GTF3C2, RBP5, NVL, NARG2, PTPLAD2, OTOF—2, CA10, RASGRP4, ALX1, C11orf48, LYRM7, MGAT5B, MKLN1, RTDR1, STXBP4, COX11, C11orf83, SNCA, POLD4, CLNS1A, DNAJC19, JAM2, ITGA4, DGUOK, LOC387647, ABCA5, NUBPL, SNRPF, CA10, PSCA, BC035336, DDX11, KCNIP4, PDIA3p, INGX, NLGN2 and POM121.
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A method for treating a patient having an autism spectrum disorder or at risk for having an autism spectrum disorder comprising administering a therapy to the patient, wherein the patient was previously determined to have an increased or decreased level of methylation in two or more of the genes selected from the group consisting of NGDN, HAL, S100A1, OTOF—1, MTBP, MRPL13, HOXB6, KAZN, MORC2, LCK, ZNF248, ANAPC7, SECT, THOC6, HCFC1R1, ABCE1, ANAPC10, DDX18, CD1D, ALKBH6, S100A13, SPIN3, LALBA, EIF4A1, CENPF, AIRE, ANKRD13C, GHSR, EIF3G, NOLC1, TPX2, BDNF, FAM149B1, ECD, OGG1, KATNAL1, IGFBP5, MRPS15, HIST1H4K, CMYA5, ARMC1, LOC286002, PAIP2, MARCKS, DNAJC25, BLZF1, NME7, C12orf26, CCDC59, MCRS1, RBM4B, MIR548H4, TEKT1, TMEM184C, TTC22, FAM164A, PACRGL, CCDC58, TMEM126B, BLCAP, LOC100131564, GTF3C2, REPS, NVL, NARG2, PTPLAD2, OTOF—2, CA10, RASGRP4, CES1, ALX1, C11orf48, LYRM7, MGAT5B, MKLN1, RTDR1, STXBP4, COX11, C11orf83, SNCA, POLD4, CLNS1A, DNAJC19, JAM2, ITGA4, DGUOK, LOC387647, ABCA5, NUBPL, SNRPF, CA10, PSCA, BC035336, DDX11, KCNIP4, PDIA3p, INGX, NLGN2 and POM121 relative to a reference level.
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Dependencies are inferred from the claim text.