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US 2014/0349973 A1Published application
Metalloenzyme inhibitor compounds
AssigneeViamet Pharmaceuticals, Inc.
InventorsWilliam J. Hoekstra, Christopher M. Yates
Life of this patent
Estimating the term…
Abstract
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Claims24
A compound of formula (I), wherein:
- R1 is halo;
- R2 is halo;
- each R3 is independently cyano, haloalkyl, alkoxy, halo, haloalkoxy, hydroxy, amino, —NR6R9, —SR10, —C(O)R10, optionally substituted haloalkyl, optionally substituted arylalkoxy, —C(O)NR6R7, —CH(OH)-haloalkyl, optionally substituted alkyl, hydroxyalkyl, alkoxyalkyl, isocyano, cycloalkylaminocarbonyl, optionally substituted aryloxyalkyl, optionally substituted arylalkylthio, haloalkylthio, optionally substituted arylalkylsulfonyl, optionally substituted arylalkylsulfinyl, optionally substituted heteroarylalkoxy, optionally substituted arylthioalkyl, or haloalkylcarbonyl;
- n is 0, 1, 2 or 3;
- R4 is aryl optionally substituted with 0, 1, 2 or 3 independent R8;
- R5 is H, alkyl, phosphato, phosphito, alkoxyphosphato, or —C(O)alkyl optionally substituted with 1 or 2 amino;
- R6 is independently H or alkyl;
- R7 is independently H, optionally substituted alkyl, optionally substituted haloalkyl, or optionally substituted arylalkyl;
- each R8 is independently cyano, haloalkyl, alkoxy, halo, or haloalkoxy;
- each R9 is independently H, alkyl, —C(O)alkyl, —C(O)H, —C(O)haloalkyl, optionally substituted arylalkyl, or optionally substituted haloalkyl;
- each R10 is independently H, optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocycloalkyl, or optionally substituted arylalkyl;
- Ar2 is
- R11 is optionally substituted phenyl, optionally substituted alkyl, optionally substituted thienyl, pyrrolyl, furanyl, optionally substituted pyridyl, —CH(OH)-alkyl, —CH(OH)-haloalkyl, optionally substituted arylalkyl, optionally substituted aryloxyalkyl, haloalkyl, haloalkoxyalkyl, optionally substituted indolyl, optionally substituted benzofuranyl, heterocycloalkyl, or
- R12 is R4, —C(O)R4, —C(O)R7, —SO2R4;
- MBG is optionally substituted tetrazolyl, optionally substituted triazolyl, optionally substituted oxazolyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted pyrazolyl.
12 more elements
-40. (canceled)
-50. (canceled)
-55. (canceled)
-63. (canceled)
Dependencies are inferred from the claim text.