Compositions and methods for treating neoplastic diseases
AssigneesDana-Farber Cancer Institute, Inc., Triphase Research and Development I Corp.
InventorsKenneth C. Anderson, Dharminder Chauhan, Michael A. Palladino
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Abstract
Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.
Claims23
1-11. (canceled)
A method of treating a neoplastic disease, comprising administering to a patient inflicted with the neoplastic disease a compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein X is selected from the group consisting of fluorine, chlorine, bromine or iodine, in combination with at least one additional chemotherapeutic agent;
- wherein the other chemotherapeutic agent is selected from the group consisting of dexamethasone, doxorubicin, and thalidomide.
(canceled)
-24. (canceled)
A pharmaceutical composition, comprising:
- a compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein X is selected from the group consisting of fluorine, chlorine, bromine or iodine;
- and
- at least one additional chemotherapeutic agent.
A method of treating a neoplastic disease, comprising administering to a patient inflicted with the neoplastic disease a synergistic combination of at least two proteosome inhibitors.
Dependencies are inferred from the claim text.