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AssigneeThe University of Tokyo
InventorsKunio SHIOTA, Shintaro YAGI, Koji HAYAKAWA, Mitsuko HIROSAWA-TAKAMORI, Daisuke ARAI, Keiji HIRABAYASHI
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The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked β-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.
A method for producing an orexin neuron, comprising a step of culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine.
A method for inducing an orexin neuron, comprising a step of administering an effective amount of N-acetyl-D-mannosamine to a subject in need thereof, or having an effective amount of N-acetyl-D-mannosamine taken by a subject in need thereof.
An agent for inducing an orexin neuron from a neural progenitor cell or a nerve cell, comprising N-acetyl-D-mannosamine as an active ingredient.
A method for producing an orexin neuron, comprising a step of culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine, and at least one inhibitor selected from the group consisting of a Sirtuin inhibitor and an O-linked β-N-acetylglucosamine transferase inhibitor.
A kit for inducing an orexin neuron from a neural progenitor cell or a nerve cell, comprising
A method for treating narcolepsy or eating disorder based on induction of orexin neuron in vivo, comprising a step of administering an effective amount of N-acetyl-D-mannosamine to a subject in need thereof.
Dependencies are inferred from the claim text.