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US 2014/0349962 A1Published application
Rapid two-step synthesis of anti-coagulants
AssigneeMassachusetts Institute of Technology
InventorsRobert D. ROSENBERG, Kuberab BALAGURUNATHAN
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Abstract
The present invention provides methods for the production of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, compounds thus obtained and compositions comprising same. This invention also provides applications of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, and compositions comprising same, for use in controlling coagulation and treating thrombosis.
Claims7
A compound comprising the structure of Formula:
- wherein
- R is SO3− or COCH3;
- and
- n is 1;
- and salts thereof,
- in which the compound is free of 2-O sulfated iduronic acid residues, wherein the compound possesses at least 4 times greater anti-coagulant activity than that of heparin as measured by factor Xa assays.
3 more elements
Dependencies are inferred from the claim text.