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US 2014/0349957 A1Published application
Compositions for Photodynamic Therapy Chemically Modified to Increase Epithelia Penetration and Cellular Bioavailability
AssigneeYagna Limited
InventorGiussepe Trigiante
Life of this patent
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Abstract
The present invention describes a photodynamic prodrug, i.e., a substituted 4-thiothymidine (4-TT), which is able to cross the body's epithelia tissues such as the skin, oral cavity, nasal cavity, pulmonary tract, digestive tract, and blood-brain barrier, including the use of such a prodrug in a topical application for the treatment of skin hyperplasias, including skin cancer, psoriasis, keloids, actinic keratosis, and the like.
Claims21
A method of photodynamic disruption of cells comprising:
- contacting a cell with a composition comprising a photosensitive structure as set forth in Formula (I):
- wherein R is an alkyl group or an alkylene group between 6 and 20 carbon atoms in length, an hydroxylated alkyl group or hydroxylated alkylene group between 6 and 20 carbon atoms in length, a lipoamino acid group, or a sugar acid group,
- wherein R1 is an alkyl group or an alkylene group between 1 and 15 carbon atoms in length, and wherein said structure passes through the cell membrane and into the cell interior;
- and
- applying light on said cell to cause a disruption of the cell by a photodynamic reaction of said photosensitive structure within the cell.
2 more elements
A method of treating an epithelial hyperplasia comprising:
- administering a pharmaceutically effective amount of a composition containing a photosensitive structure w a subject in need thereof, wherein said structure is as set forth in Formula (II):
- wherein n is 14, and wherein said structure passes through a cell membrane and into cell interior of a cell of the epithelial hyperplasia;
- and
- applying light on said subject,
- wherein said light induces a photodynamic reaction of said photosensitive structure within cells of the epithelial hyperplasia.
2 more elements
A kit comprising:
- (a) a composition comprising a photosensitive structure as set forth in Formula (I):
- wherein R is an alkyl group or an alkylene group between 6 and 20 carbon atoms in length, an hydroxylated alkyl group or hydroxylated alkylene group between 6 and 20 carbon atoms in length, a lipoamino acid group, or a sugar acid group, and
- wherein R1 is an alkyl group or an alkylene group having 0 to 15 carbon atoms;
- (b) a container;
- (c) optionally one or more buffers and solvents;
- (d) a label;
- and
- (e) instructions on how to apply to the composition to cells.
5 more elements
-27. (canceled)
Dependencies are inferred from the claim text.