Materials and methods for detecting and/or predicting necrotizing enterocolitis in infants
AssigneeUniversity of Florida Research Foundation, Inc.
InventorJosef Neu
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Abstract
The subject invention pertains to materials and methods for diagnosing and/or predicting pathologic infant conditions. A method of the invention comprises obtaining a biological sample from an infant and analyzing the sample to detect at least one protein biomarker of necrotizing enterocolitis (NEC), wherein a patient is diagnosed with NEC or determined to have a likelihood of developing NEC following detection of the biomarker. In another method of the invention, the likelihood of a patient developing NEC is determined. In certain embodiments, treatment is administered to the patient following diagnosis of NEC or determination that the patient has a likelihood of developing NEC.
Claims20
A method for diagnosing necrotizing enterocolitis (NEC) in an infant, wherein said method comprises:
- (a) obtaining a buccal sample from an infant patient;
- (b) analyzing the sample to detect at least one protein biomarker of NEC;
- and, based on the detection of the at least one protein biomarker, (c) diagnosing NEC in the patient.
A method for diagnosing and treating NEC in an infant, wherein said method comprises:
- (a) obtaining a buccal sample from an infant patient;
- (b) analyzing the sample to detect at least one protein biomarker of NEC selected from the group consisting of peroxiredoxin, IL-1 RA, and alpha 1 anti-trypsin;
- and, based on the detection of at least one of these protein biomarkers, (c) diagnosing NEC in the patient, and (d) treating the patient diagnosed with NEC.
A method for determining an infant's likelihood of developing NEC, comprising:
- (a) obtaining a buccal sample from an infant patient;
- (b) analyzing the sample to detect at least one protein biomarker of NEC selected from the group consisting of peroxiredoxin, IL-1RA, and alpha 1 anti-trypsin;
- and, based on the detection of the at least one protein biomarker, (c) determining the infant's likelihood of developing NEC.
Dependencies are inferred from the claim text.