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US 2014/0349952 A1Published application
Mannosylated compounds useful for the prevention and the treatment of infectious diseases
AssigneesUniversite De Strasbourg, Centre National De La Recherche Scientifique
InventorsRachid Baati, Laure Dehuyser, Christopher Mueller, Evelyne Schaeffer, Alain Wagner
Life of this patent
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Abstract
The present invention relates to new anti-infectious compounds consisting of (i) a polar head having from one to three mannose, dimannose or trimannose moieties, which is coupled through an appropriate linker to (ii) a single lipid chain of at least 17 carbon atoms of length. Pharmaceutical compositions and therapeutic uses thereof are also provided.
Claims19
1-19. (canceled)
A compound of formula (I)
- wherein:
- R1 is a C17-C30 saturated or unsaturated linear alkyl optionally substituted by one or more C1-C3 alkyl radicals,
- M2-Q2 and M3-Q3 are optionally present,
- M1 is selected from the group consisting of mannosyl, dimannosyl, and trimannosyl,
- M2 et M3 are independently selected from the group consisting of mannosyl, dimannosyl, trimannosyl, and therapeutic agent moieties having a molecular weight of at most 800 g/mol−1,
- Q1, Q2 and Q3 are independently selected from the group of oligoether-based spacers comprising at least one —(R8O)n— moiety wherein R8 is a linear or branched C1-C4 alkyl, and n is an integer from 2 to 10, and
- LINKER is selected among bifunctional, trifunctional and tetrafunctional linkers having a backbone of 1 to 20 carbon atoms and at least two heteroatoms independently selected from N, S and O,
- or a pharmaceutically acceptable salt or solvate thereof.
5 more elements
Dependencies are inferred from the claim text.