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US 2014/0349951 A1Published application
Compositions and Methods Related To Calcitriol
AssigneeVDF Futureceuticals, Inc.
InventorZbigniew Pietrzkowski
Life of this patent
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Abstract
Contemplated compositions and methods are drawn to use of various boron-containing compounds to temporarily and transiently increase endogenous blood calcitriol concentration. The boron-containing compound is preferably a carbohydrate-boron complex having sufficient stability to achieve measurable quantities of the complex in blood upon oral administration of the complex.
Claims20
A method of treating a condition associated with an abnormal calcitriol level in serum of a mammal, comprising:
- administering a carbohydrate-boron complex to the mammal at a dosage and schedule that transiently increases endogenous blood calcitriol and that simultaneously maintains endogenous blood calcidiol concentration in the mammal;
- wherein the condition is an inflammatory condition or overreaction of the immune system;
- and
- wherein the dosage and schedule are effective to transiently increase the endogenous blood calcitriol in an amount of at least 20% over baseline.
1 more element
In a method of providing a carbohydrate-boron complex to a mammal, the improvement comprising:
- administering the carbohydrate-boron complex to the mammal after the mammal is found to have an inflammatory condition or overreaction of the immune system;
- wherein the step of administering comprises administration of the carbohydrate-boron complex at a dosage and schedule that transiently increases endogenous blood calcitriol and that simultaneously maintains endogenous blood calcidiol concentration in the mammal;
- and
- wherein the dosage and schedule are effective to transiently increase the endogenous blood calcitriol in an amount of at least 20% over baseline.
1 more element
Dependencies are inferred from the claim text.