Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides
AssigneeInstitut Pasteur
InventorsCatherine ROUGEOT, Jean-Francois HUAULME, Marie-Noelle UNGEHEUER, Anne WISNER, Evelyne DUFOUR
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Abstract
The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of Basic Proline-rich Lacrimal Protein (BPLP) or of any of its maturation products, by detecting, or quantifying in a biological sample of a test subject, a BPLP protein or a maturation product thereof, and comparing the production of BPLP protein or maturation product with the production of the same in a biological sample of a control subject
Claims22
An in vitro method for the prognosis, diagnosis or determination of the evolution of a condition involving an altered production of a Basic Proline-rich Lacrimal Protein (BPLP) or of any of its maturation products, which method comprises detecting, or quantifying in a biological sample of a test subject, a BPLP protein or maturation product thereof, and comparing the production of BPLP protein or maturation product with the production of the same in a biological sample of a control subject.
2-13. (canceled)
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an isolated peptide,
- wherein the peptide comprises the sequence Glu-Arg-Phe-Ser-Arg (SEQ ID NO:
- 3) or Glp-Arg-Phe-Ser-Arg (SEQ ID NO:
- 7), and
- wherein the peptide exhibits an inhibitory property against a neutral endopeptidase or an aminopeptidase.
A method for treating pain comprising administering an isolated peptide comprising less than 15 amino acids to a human subject,
- wherein the peptide comprises the sequence Glu-Arg-Phe-Ser-Arg (SEQ ID NO:
- 3) or Glp-Arg-Phe-Ser-Arg (SEQ ID NO:
- 7), and
- wherein the peptide exhibits an inhibitory property against a neutral endopeptidase or an aminopeptidase.
Dependencies are inferred from the claim text.