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US 2014/0349944 A1Published application
Chaperone-based integrin inhibitors for the treatment of cancer and inflammatory diseases
AssigneeMUSC Foundation for Research Development
InventorsZihai LI, Feng HONG
Life of this patent
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Abstract
The present disclosure provides isolated integrin αL polypeptides, such as α7 helix polypeptides from the alpha I domain of integrin. Such polypeptides inhibit the interaction between integrin and gp96, thereby inhibiting gp96 activity. Such inhibition can be used to prevent cancer cell growth, cancer metastasis and/or inflammation.
Claims20
An isolated polypeptide comprising the α7 helix peptide domain from integrin or a sequence having 1 or 2 amino acid substitutions, deletions or insertions relative to the α7 helix peptide domain, wherein the polypeptide is not a full length integrin polypeptide.
Dependencies are inferred from the claim text.