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US 2014/0349926 A1Published application
Formulations for the treatment of diabetes
AssigneeXeris Pharmaceuticals, Inc.
InventorsSteven Prestrelski, Nancy Scott
Life of this patent
Estimating the term…
Abstract
Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.
Claims37
A formulation for parenteral administration comprising:
- (a) insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and has been previously dried from a non-volatile buffer;
- and
- (b) an aprotic polar solvent,
- wherein the insulin is solubilized in the aprotic polar solvent, wherein the majority of the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and
- wherein the water content of the formulation is equal to or less than 15% w/v.
2 more elements
The formulation of 26, wherein the formulation is a solution.
35-38. (canceled)
40-50. (canceled)
Dependencies are inferred from the claim text.