Long-acting glp-1/glucagon receptor agonists
OwnerUdi Eyal Fima, Oren Hershkóvitzinventors
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Abstract
Pegylated and reverse pegylated GLP-1/Glucaron receptor agonists including pharmaceutical compositions comprising the same and methods of using the same are disclosed.
Claims39
A composition consisting of an oxyntomodulin, a polyethylene glycol polymer (PEG polymer) and 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS).
A method for extending the biological half life of oxyntomodulin, consisting of the step of conjugating oxyntomodulin, a polyethylene glycol polymer (PEG polymer) and 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) in a molar ratio of about 1:1:0.5 to about 1:1:3.5.
A method of improving the area under the curve (AUC) of oxyntomodulin, consisting of the step of conjugating a polyethylene glycol polymer (PEG polymer) to the amino terminus of said oxyntomodulin via 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS).
A method of reducing the dosing frequency of oxyntomodulin, consisting of the step of conjugating a polyethylene glycol polymer (PEG polymer) to the amino terminus of said oxyntomodulin via 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS).
A method for reducing food intake, reducing body weight, or both in a subject, comprising the step of administering oxyntomodulin conjugated to polyethylene glycol polymer (PEG polymer) via a flexible linker to said subject, wherein said flexible linker is 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS).
A method for increasing insulin sensitivity in a subject, comprising the step of administering to the subject an effective amount of a composition comprising oxyntomodulin conjugated to polyethylene glycol polymer (PEG polymer).
Dependencies are inferred from the claim text.