Apparatus for the processing of single molecules
AssigneeKoninklijke Philips N.V.
InventorsPieter Jan Van Der Zaag, Reinder Coehoorn, Falco Cornelius Marinus Jacobus Maria Van Delft
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Abstract
The invention relates to an apparatus(100) and a method for the processing of single molecules, particularly for the sensing or sequencing of single-stranded DNA. A bottom layer(110) and an electrically conductive top layer(120) with a first and a second slit(111,121), respectively, are disposed on top of each other such that an aperture(A) is formed by the slits. The slits(111,121) are preferably perpendicular to each other. An electrical circuit(140) may be connected to the top layer(120), allowing to sense single molecules that pass through the aperture(A).
Claims15
An apparatus (100, 200) for the processing of single molecules (M), comprising:
- a) a bottom layer (110, 210) with a first slit (111);
- b) an electrically conductive top layer (120, 220) that is disposed on the bottom layer (110, 210) and that has a second slit (121) which is disposed above the first slit (111) to provide an aperture (A) through which single molecules (M) can pass, wherein the first slit is oriented oblique to the second slit.
A method for the processing of single molecules (M), comprising the following steps:
- a) letting a molecule (M) sequentially pass a second slit (121) in an electrically conductive top layer (120, 220) and a first slit (111) in an adjacent bottom layer (110, 210), wherein the first slit is oriented oblique to the second slit, and wherein said slits provide an aperture (A);
- b) executing or sensing interactions between the molecule and the top layer (120, 220) and/or the bottom layer (110, 210) when the molecules (M) passes through said aperture (A).
(canceled)
Dependencies are inferred from the claim text.