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US 2014/0349880 A1Published application
Novel antibiotic preparation method and platform system based on same
AssigneeProtein Design Lab, Ltd.
InventorXiaoqing Qiu
Life of this patent
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Abstract
Provided are a novel antibiotic preparation method and platform system based on the method, belonging to a novel drug development method. The method is based on a fixed structural formula: F—R, wherein F is an effect area, and R is an identification area. At the prior art level, the present invention can quickly develop a specific novel antibiotic for most pathogenic microorganisms or biological cells. Also provided is a platform for implementing the method, ensuring that the novel antibiotic is developed in an efficient streamlined process.
Claims12
1-16. (canceled)
A novel antibiotic preparation method, comprising steps as follows:
- (1) determining targets:
- said targets refer to prokaryotic cells, eukaryotic cells, viruses or products thereof which said novel antibiotic will react against directly;
- (2) designing molecular structure of said novel antibiotic:
- said molecular structure of said novel antibiotic is designed according to the following general formula:
- wherein, R is recognition region, which specifically recognizes or combines said targets;
- F is effect region, which generates pharmaceutical effects to targets, and said pharmaceutical effects are regulating, repairing, labeling, causing death and/or collapsing against said targets specifically;
- establishing recognition region molecular structure library;
- establishing effect region molecular structure library;
- according to said general formula, designing recombinant molecular structure library on the basis of said recognition region molecular structure library and effect region molecular structure library;
- said designing refers to the process of structural readjustment, structural recombination and/or structural confirmation carried out on the basis of molecular structures of collected, selected or prepared substances used as effect region or recognition region;
- (3) based on said recombinant molecular structure library, preparing and verifying recombinant so as to obtain candidate novel antibiotics;
- (4) screening novel antibiotics which meet requirements as medicine from candidate novel antibiotics,
- wherein said establishing recognition region molecular structure library refers to artificially preparing artificial substances which specifically recognize and/or combine said targets as well as obtaining molecular structure thereof,
- said artificial substances refer to antibody mimetic, said antibody mimetic is designed according to amino acid sequence of immunoglobulin which can specifically recognize unique substance on said targets,
- wherein said immunoglobulin is prepared by taking multiple unique substances on target as immunogens to immunize animal respectively.
12 more elements
Dependencies are inferred from the claim text.