Methods and compositions for monitoring and risk prediction in cardiorenal syndrome

A method of monitoring cardiorenal syndrome a patient, comprising:

• (a) performing an assay method that detects NGAL on a body fluid sample obtained from said patient, thereby providing an NGAL assay result;
• (b) performing an assay method that detects one or more of BNP, NT-proBNP and proBNP on the same or a different body fluid sample obtained from said patient, thereby providing a natriuretic peptide assay result;
• and
• (c) relating the NGAL assay result and the natriuretic peptide assay result to the patient's cardiorenal syndrome status by
• (i) comparing said NGAL assay result to a baseline NGAL result, and assigning a worsening cardiorenal syndrome status to said patient when said NGAL assay result is greater than said baseline NGAL result, relative to a status assigned when said NGAL assay result is less than said baseline NGAL result, or by assigning an improving cardiorenal syndrome status to said patient when said NGAL assay result is less than said baseline NGAL result, relative to a status assigned when said NGAL assay result is greater than said baseline NGAL result, and
• (ii) comparing said natriuretic peptide assay result to a baseline natriuretic peptide result, and assigning a worsening cardiorenal syndrome status to said patient when said natriuretic peptide assay result is greater than said baseline natriuretic peptide result, relative to a status assigned when said natriuretic peptide assay result is less than said baseline natriuretic peptide result, or by assigning an improving cardiorenal syndrome status to said patient when said natriuretic peptide assay result is less than said baseline natriuretic peptide result, relative to a status assigned when said natriuretic peptide assay result is greater than said baseline natriuretic peptide result.