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US 2014/0349856 A1Published application
Neuroendocrine Tumors
AssigneeBiotheranostics, Inc.
InventorsCatherine A. Schnabel, Yi Zhang, Mark G. Erlander
Life of this patent
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Abstract
The disclosure provides methods for the use of gene expression measurements to classify or identify neuroendocrine cancer in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
Claims20
A method of classifying a cell containing sample as containing neuroendocrine tumor cells, said method comprising
- detection of expressed RNAs, or cDNA copies thereof, to determine the expression levels of one or more sequences selected from AY033998 (SEQ ID NO:
- 3) (ELAV4), BC015754 (SEQ ID NO:
- 4) (CADPS), BC013117 (SEQ ID NO:
- 12) (RGS17) and AI309080 (SEQ ID NO:
- 9) (KCNJ11) in cancer cells of a sample obtained from a human subject,
- comparison of said expression levels to expression levels of the same transcribed sequences in known neuroendocrine tumor specimens;
- and
- classification of the sample as containing or not containing neuroendocrine tumor cells.
5 more elements
A method of classifying a cell containing sample as containing a subtype of neuroendocrine tumor cells, said method comprising
- detection of expressed RNAs, or cDNA copies thereof, to determine the expression levels of one or more sequences in cancer cells of a sample obtained from a human subject,
- comparison of said expression levels to expression levels of the same transcribed sequences in known neuroendocrine tumor specimens of adrenal-pheochromocytoma/paraganglioma, gastrointestinal neuroendocrine tumor, pulmonary carcinoid, pulmonary small cell or large cell carcinoma, pancreatic neuroendocrine tumor, Merkel cell carcinoma, and medullary thyroid carcinoma;
- and
- classification of the sample as containing or a neuroendocrine tumor selected from adrenal-pheochromocytoma/paraganglioma, gastrointestinal neuroendocrine tumor, pulmonary carcinoid, pulmonary small cell or large cell carcinoma, pancreatic neuroendocrine tumor, Merkel cell carcinoma, and medullary thyroid carcinoma.
1 more element
Dependencies are inferred from the claim text.