Endothelial cell production by programming
AssigneeCellular Dynamics International, Inc.
InventorsJunying YU, Maksym A. VODYANYK
Life of this patent
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Abstract
The invention generally regards methods for providing endothelial cells and precursors of endothelial cells from a variety of cell sources, such as pluripotent stem cells. Also provided are therapeutic compositions including the provided endothelial cells, and methods of using them for the treatment of subjects.
Claims8
-26. (canceled)
A cell population comprising human endothelial cells, wherein at least 80% of the endothelial cells comprise an exogenous expression cassette that comprises one or more endothelial programming factor genes, said one or more endothelial programming factors or gene products of such genes comprises an ETV2 and/or ERG gene or gene product or an isoform thereof.
A cell population comprising human endothelial progenitor cells, wherein at least 80% of the endothelial progenitor cells comprise an exogenous expression cassette that comprises one or more endothelial programming factor genes, said one or more endothelial programming factors or gene products of such genes comprises an ETV2 and/or ERG gene or gene product or an isoform thereof.
Dependencies are inferred from the claim text.