Reprogramming immortalized b cells
AssigneeCellular Dynamics International, Inc.
InventorsJames THOMSON, Deepika RAJESH, Sarah Jane DICKERSON, Amanda MACK, Michael MILLER
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Abstract
Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
Claims7
-16. (canceled)
A human iPS cell having a genome that comprises an incomplete set of B cell immunoglobin variable region genes compared with an embryonic stem cell, wherein the iPS cell is essentially free of exogenous genetic elements.
Dependencies are inferred from the claim text.