Baculovirus system for the expression of a gene therapy vector
AssigneeGenethon
InventorsLionel Galibert, Otto-Wilhelm Merten, Aurélien Jacob
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Abstract
The invention concerns a recombinant baculovirus genome useful for the expression of gene therapy vectors by means of a single infection.
Claims17
A recombinant baculovirus genome comprising one or more expression cassettes for the protein components required for the production of a heterologous viral vector, and a recombinant genome of a heterologous viral vector, said expression cassettes and said recombinant genome of a heterologous viral vector being inserted into one or more locus selected from the group consisting of the egt, polyhedrin, ctx, 39k, orf51, gp37, iap2 and odv-e56, p10 and p94 loci.
A recombinant baculovirus genome comprising one or more expression cassettes for the AAV rep and/or cap genes, said one or more expression cassettes being inserted into a locus selected from the group consisting of the egt, ctx, 39k, orf51, gp37, iap2, odv-e56, p10 and p94 loci of the baculovirus genome.
Dependencies are inferred from the claim text.