Sclareol and labdenediol diphosphate synthase polypeptides, encoding nucleic acid molecules and uses thereof
AssigneeAllylix, Inc.
InventorsGrace Eunyoung Park, Bryan N. Julien, Richard Burlingame
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Abstract
Provided are labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides, nucleic acid molecules encoding the labdenediol diphosphate synthase polypeptides and sclareol synthase polypeptides, and methods of using the labdenediol diphosphate synthase polypeptides, sclareol synthase polypeptides. Also provided are methods for producing labdenediol diphosphate, sclareol and (−)-ambroxide.
Claims40
An isolated recombinant Nicotiana glutinosa labdenediol diphosphate synthase.
An isolated recombinant Nicotiana glutinosa sclareol synthase.
A nucleic acid molecule encoding a fusion protein, comprising:
- a) a Nicotiana glutinosa labdenediol diphosphate synthase or a catalytically active fragment thereof;
- and
- b) a Nicotiana glutinosa sclareol synthase or a catalytically active fragment thereof, wherein a) and b) are linked directly or via a linker.
Dependencies are inferred from the claim text.