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US 2014/0349334 A1Published application
Non-invasive imaging to the blastocyst stage for the detection of human embryonic aneuploidy
AssigneeThe Board of Truestees of the Leland Stanford Junior University
InventorsShawn L. Chavez, Brooke Friedman, Barry Behr, Renee A. Reijo Pera
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Abstract
Methods are provided for the non-invasive imaging of embryos to determine whether they are euploid or aneuploid.
Claims12
A method for determining the quality of a human embryo growing in vitro, comprising:
- measuring at least one imaging parameter of a test embryo, selected from (P1) duration of the first cytokinesis;
- (P2) time between 2nd and 3rd cell (or first and second mitosis);
- (P3) time between 3rd and 4th cell (or second and third mitosis);
- (P4) time between 4th and 5th cell;
- (P5) time between 5th cell and compaction;
- (P6) time between 5th cell and cavitation;
- comparing the at least one imaging parameter from the test embryo to a reference imaging parameter;
- determining whether the at least one imaging parameter from the test embryo differs from the reference imaging parameter;
- wherein a difference indicates a lack of embryo quality;
- and
- providing an evaluation of the test embryo quality based on the at least one imaging parameter.
8 more elements
Dependencies are inferred from the claim text.