Back to results
US 2014/0349320 A1Published application
Using Adaptive Immunity to Detect Drug Resistance
AssigneeThe Trustees of the University of Pennsylvania
InventorsGregory P. Bisson, Drew Weissman, Harvey Rubin
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of using adaptive immunity to detect drug resistance in infectious diseases. The invention provides novel antigens associated with drug resistant MTB infection.
Claims20
A method of assessing microbial infection in a mammal, the method comprising:
- a) contacting at least one polypeptide that is differentially expressed in a drug-resistant strain compared to a corresponding drug-susceptible strain with a biological sample from the mammal;
- and
- b) measuring an immune response in the biological sample, wherein an increase in the immune response to the at least one polypeptide that is differentially expressed in a drug-resistant strain compared to a corresponding drug-susceptible strain in the biological sample of the mammal indicates a past or present microbial infection with a drug-resistant strain.
A kit for use in determining the presence of a drug-resistant strain in a mammal, the kit comprising at least one polypeptide that is differentially expressed in a drug-resistant strain compared to a corresponding drug-susceptible strain.
Dependencies are inferred from the claim text.