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US 2014/0349306 A1Published application
Novel human exosomal proteins and use thereof
AssigneeKonkuk University Industrial Cooperation Corp.
InventorsHyewon CHUNG, Hyung-Soon PARK, Hyun-Jung LIM
Life of this patent
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Abstract
There are provided novel human exosomal proteins and use thereof.
Claims4
An exosomal protein composition comprising proteins having gene information numbers listed in the following Table:
- No.
- Accession #
- Protein Name
- 1
- 207028673
- aldo-keto reductase family 1 member C2
- isoform 2 [Homo sapiens]
- 2
- 4502261
- antithrombin-III precursor [Homo sapiens]
- 3
- 206597441
- aldehyde dehydrogenase, dimeric NADP-preferring
- [Homo sapiens]
- 4
- 4502491
- complement component 1 Q subcomponent-binding
- protein, mitochondrial precursor [Homo sapiens]
- 5
- 5031777
- isocitrate dehydrogenase [NAD] subunit alpha,
- mitochondrial precursor [Homo sapiens]
- 6
- 24234747
- interleukin enhancer-binding factor 2
- [Homo sapiens]
- 7
- 46094076
- tsukushin precursor [Homo sapiens]
- 8
- 4501989
- alpha-fetoprotein precursor [Homo sapiens]
- 9
- 260064050
- alpha-2-antiplasmin isoform b precursor
- [Homo sapiens]
- 10
- 4503519
- eukaryotic translation initiation factor 3
- subunit F [Homo sapiens]
- 11
- 217272892
- 116 kDa U5 small nuclear ribonucleoprotein
- component isoform a [Homo sapiens]
- 12
- 14149738
- neurolysin, mitochondrial precursor
- [Homo sapiens]
- 13
- 15451921
- platelet-derived growth factor D isoform 2
- precursor [Homo sapiens]
- 14
- 4885649
- SUMO-activating enzyme subunit 2
- [Homo sapiens]
- 15
- 290560750
- hepatitis A virus cellular receptor 1 precursor
- [Homo sapiens]
- 16
- 32483374
- nucleolar protein 56 [Homo sapiens]
- 17
- 7305503
- stomatin-like protein 2 [Homo sapiens]
- 18
- 71773106
- AP-2 complex subunit beta isoform a
- [Homo sapiens]
- 19
- 169218225
- PREDICTED:
- u5 small nuclear ribonucleoprotein
- 200 kDa helicase-like, partial [Homo sapiens]
- 20
- 45446745
- aldo-keto reductase family 1 member C2
- isoform 1 [Homo sapiens]
- 21
- 24497583
- aldo-keto reductase family 1 member C3
- [Homo sapiens]
- 22
- 14141161
- heterogeneous nuclear ribonucleoprotein U
- isoform b [Homo sapiens]
- 23
- 4885377
- histone H1.3 [Homo sapiens]
- 24
- 291291012
- putative aldo-keto reductase family 1
- member B15 [Homo sapiens]
- 25
- 205277471
- cochlin precursor [Homo sapiens]
- 26
- 258613957
- aspartyl/asparaginyl beta-hydroxylase
- isoform 1 [Homo sapiens]
- 27
- 4505047
- lumican precursor [Homo sapiens]
- 28
- 4503635
- prothrombin preproprotein [Homo sapiens]
- 29
- 15890086
- collagen alpha-5(IV) chain isoform 2
- precursor [Homo sapiens]
- 30
- 47578117
- phosphatidylinositol 3,4,5-trisphosphate-
- dependent Rac exchanger 2 protein
- isoform b [Homo sapiens]
- 31
- 290656011
- neogenin isoform 2 precursor [Homo sapiens]
- 32
- 5454158
- valyl-tRNA synthetase [Homo sapiens]
- 33
- 20544168
- histone H1t [Homo sapiens]
- 34
- 22035638
- microsomal glutathione S-transferase 1
- [Homo sapiens]
- 35
- 55770836
- probable saccharopine dehydrogenase
- [Homo sapiens]
- 36
- 153945728
- microtubule-associated protein 1B
- [Homo sapiens]
- 37
- 83376130
- elongation factor 1-beta [Homo sapiens]
- 38
- 296317339
- voltage-dependent anion-selective channel
- protein 2 isoform 2 [Homo sapiens]
- 39
- 133925811
- transportin-1 isoform 1 [Homo sapiens]
- 40
- 208431836
- polyadenylate-binding protein 4 isoform 3
- [Homo sapiens]
- 41
- 28373105
- sarcoplasmic/endoplasmic reticulum calcium
- ATPase 3 isoform e [Homo sapiens]
- 42
- 15431301
- 60S ribosomal protein L7 [Homo sapiens]
- 43
- 46593007
- cytochrome b-c1 complex subunit 1, mitochondrial
- precursor [Homo sapiens]
- 44
- 38327552
- ras GTPase-activating protein-binding
- protein 1 [Homo sapiens]
- 45
- 21396489
- lon protease homolog, mitochondrial
- precursor [Homo sapiens]
- 46
- 148277071
- thioredoxin reductase 1, cytoplasmic
- isoform 3 [Homo sapiens]
- 47
- 148596949
- nucleolar and coiled-body phosphoprotein 1
- [Homo sapiens]
- 48
- 4504425
- high mobility group protein B1
- [Homo sapiens]
- 49
- 148491070
- CTP synthase 1 [Homo sapiens]
182 more elements
A composition for diagnosing an age-related macular degeneration, the composition comprising at least one protein selected from the group consisting of proteins having gene information numbers listed in the following Table or antibodies against the proteins:
- No.
- Accession #
- Protein Name
- 1
- 207028673
- aldo-keto reductase family 1 member C2
- isoform 2 [Homo sapiens]
- 2
- 4502261
- antithrombin-III precursor [Homo sapiens]
- 3
- 206597441
- aldehyde dehydrogenase, dimeric NADP-preferring
- [Homo sapiens]
- 4
- 4502491
- complement component 1 Q subcomponent-binding
- protein, mitochondrial precursor
- [Homo sapiens]
- 5
- 5031777
- isocitrate dehydrogenase [NAD] subunit alpha,
- mitochondrial precursor [Homo sapiens]
- 6
- 24234747
- interleukin enhancer-binding factor 2
- [Homo sapiens]
- 7
- 46094076
- tsukushin precursor [Homo sapiens]
- 8
- 4501989
- alpha-fetoprotein precursor [Homo sapiens]
- 9
- 260064050
- alpha-2-antiplasmin isoform b precursor
- [Homo sapiens]
- 10
- 4503519
- eukaryotic translation initiation factor 3
- subunit F [Homo sapiens]
- 11
- 217272892
- 116 kDa U5 small nuclear ribonucleoprotein
- component isoform a [Homo sapiens]
- 12
- 14149738
- neurolysin, mitochondrial precursor
- [Homo sapiens]
- 13
- 15451921
- platelet-derived growth factor D isoform 2
- precursor [Homo sapiens]
- 14
- 4885649
- SUMO-activating enzyme subunit 2
- [Homo sapiens]
- 15
- 290560750
- hepatitis A virus cellular receptor 1 precursor
- [Homo sapiens]
- 16
- 32483374
- nucleolar protein 56 [Homo sapiens]
- 17
- 7305503
- stomatin-like protein 2 [Homo sapiens]
- 18
- 71773106
- AP-2 complex subunit beta isoform a
- [Homo sapiens]
- 19
- 169218225
- PREDICTED:
- u5 small nuclear ribonucleoprotein
- 200 kDa helicase-like, partial
- [Homo sapiens]
- 20
- 45446745
- aldo-keto reductase family 1 member C2
- isoform 1 [Homo sapiens]
- 21
- 24497583
- aldo-keto reductase family 1 member C3
- [Homo sapiens]
- 22
- 14141161
- heterogeneous nuclear ribonucleoprotein U
- isoform b [Homo sapiens]
- 23
- 4885377
- histone H1.3 [Homo sapiens]
- 24
- 291291012
- putative aldo-keto reductase family 1
- member B15 [Homo sapiens]
- 25
- 205277471
- cochlin precursor [Homo sapiens]
- 26
- 258613957
- aspartyl/asparaginyl beta-hydroxylase
- isoform 1 [Homo sapiens]
- 27
- 4505047
- lumican precursor [Homo sapiens]
- 28
- 4503635
- prothrombin preproprotein [Homo sapiens]
- 29
- 15890086
- collagen alpha-5(IV) chain isoform 2
- precursor [Homo sapiens]
- 30
- 47578117
- phosphatidylinositol 3,4,5-trisphosphate-
- dependent Rac exchanger 2 protein
- isoform b [Homo sapiens]
- 31
- 290656011
- neogenin isoform 2 precursor [Homo sapiens]
- 32
- 5454158
- valyl-tRNA synthetase [Homo sapiens]
- 33
- 20544168
- histone H1t [Homo sapiens]
- 34
- 22035638
- microsomal glutathione S-transferase 1
- [Homo sapiens]
- 35
- 55770836
- probable saccharopine dehydrogenase
- [Homo sapiens]
- 36
- 153945728
- microtubule-associated protein 1B
- [Homo sapiens]
- 37
- 83376130
- elongation factor 1-beta [Homo sapiens]
- 38
- 296317339
- voltage-dependent anion-selective channel
- protein 2 isoform 2 [Homo sapiens]
- 39
- 133925811
- transportin-1 isoform 1 [Homo sapiens]
- 40
- 208431836
- polyadenylate-binding protein 4 isoform 3
- [Homo sapiens]
- 41
- 28373105
- sarcoplasmic/endoplasmic reticulum calcium
- ATPase 3 isoform e [Homo sapiens]
- 42
- 15431301
- 60S ribosomal protein L7 [Homo sapiens]
- 43
- 46593007
- cytochrome b-c1 complex subunit 1, mitochondrial
- precursor [Homo sapiens]
- 44
- 38327552
- ras GTPase-activating protein-binding
- protein 1 [Homo sapiens]
- 45
- 21396489
- lon protease homolog, mitochondrial
- precursor [Homo sapiens]
- 46
- 148277071
- thioredoxin reductase 1, cytoplasmic
- isoform 3 [Homo sapiens]
- 47
- 148596949
- nucleolar and coiled-body phosphoprotein 1
- [Homo sapiens]
- 48
- 4504425
- high mobility group protein B1
- [Homo sapiens]
- 49
- 148491070
- CTP synthase 1 [Homo sapiens]
184 more elements
A composition for diagnosing an age-related macular degeneration, the composition comprising proteins having gene information numbers listed in the following Table or antibodies against the proteins:
- No.
- Accession #
- Protein Name
- 1
- 207028673
- aldo-keto reductase family 1 member C2
- isoform 2 [Homo sapiens]
- 2
- 4502261
- antithrombin-III precursor [Homo sapiens]
- 3
- 206597441
- aldehyde dehydrogenase, dimeric NADP-preferring
- [Homo sapiens]
- 4
- 4502491
- complement component 1 Q subcomponent-binding
- protein, mitochondrial precursor
- [Homo sapiens]
- 5
- 5031777
- isocitrate dehydrogenase [NAD] subunit alpha,
- mitochondrial precursor [Homo sapiens]
- 6
- 24234747
- interleukin enhancer-binding factor 2
- [Homo sapiens]
- 7
- 46094076
- tsukushin precursor [Homo sapiens]
- 8
- 4501989
- alpha-fetoprotein precursor [Homo sapiens]
- 9
- 260064050
- alpha-2-antiplasmin isoform b precursor
- [Homo sapiens]
- 10
- 4503519
- eukaryotic translation initiation factor 3
- subunit F [Homo sapiens]
- 11
- 217272892
- 116 kDa U5 small nuclear ribonucleoprotein
- component isoform a [Homo sapiens]
- 12
- 14149738
- neurolysin, mitochondrial precursor
- [Homo sapiens]
- 13
- 15451921
- platelet-derived growth factor D isoform 2
- precursor [Homo sapiens]
- 14
- 4885649
- SUMO-activating enzyme subunit 2
- [Homo sapiens]
- 15
- 290560750
- hepatitis A virus cellular receptor 1 precursor
- [Homo sapiens]
- 16
- 32483374
- nucleolar protein 56 [Homo sapiens]
- 17
- 7305503
- stomatin-like protein 2 [Homo sapiens]
- 18
- 71773106
- AP-2 complex subunit beta isoform a
- [Homo sapiens]
- 19
- 169218225
- PREDICTED:
- u5 small nuclear ribonucleoprotein
- 200 kDa helicase-like, partial
- [Homo sapiens]
- 20
- 45446745
- aldo-keto reductase family 1 member C2
- isoform 1 [Homo sapiens]
- 21
- 24497583
- aldo-keto reductase family 1 member C3
- [Homo sapiens]
- 22
- 14141161
- heterogeneous nuclear ribonucleoprotein U
- isoform b [Homo sapiens]
- 23
- 4885377
- histone H1.3 [Homo sapiens]
- 24
- 291291012
- putative aldo-keto reductase family 1
- member B15 [Homo sapiens]
- 25
- 205277471
- cochlin precursor [Homo sapiens]
- 26
- 258613957
- aspartyl/asparaginyl beta-hydroxylase
- isoform 1 [Homo sapiens]
- 27
- 4505047
- lumican precursor [Homo sapiens]
- 28
- 4503635
- prothrombin preproprotein [Homo sapiens]
- 29
- 15890086
- collagen alpha-5(IV) chain isoform 2
- precursor [Homo sapiens]
- 30
- 47578117
- phosphatidylinositol 3,4,5-trisphosphate-
- dependent Rac exchanger 2 protein
- isoform b [Homo sapiens]
- 31
- 290656011
- neogenin isoform 2 precursor [Homo sapiens]
- 32
- 5454158
- valyl-tRNA synthetase [Homo sapiens]
- 33
- 20544168
- histone H1t [Homo sapiens]
- 34
- 22035638
- microsomal glutathione S-transferase 1
- [Homo sapiens]
- 35
- 55770836
- probable saccharopine dehydrogenase
- [Homo sapiens]
- 36
- 153945728
- microtubule-associated protein 1B
- [Homo sapiens]
- 37
- 83376130
- elongation factor 1-beta [Homo sapiens]
- 38
- 296317339
- voltage-dependent anion-selective channel
- protein 2 isoform 2 [Homo sapiens]
- 39
- 133925811
- transportin-1 isoform 1 [Homo sapiens]
- 40
- 208431836
- polyadenylate-binding protein 4 isoform 3
- [Homo sapiens]
- 41
- 28373105
- sarcoplasmic/endoplasmic reticulum calcium
- ATPase 3 isoform e [Homo sapiens]
- 42
- 15431301
- 60S ribosomal protein L7 [Homo sapiens]
- 43
- 46593007
- cytochrome b-c1 complex subunit 1, mitochondrial
- precursor [Homo sapiens]
- 44
- 38327552
- ras GTPase-activating protein-binding
- protein 1 [Homo sapiens]
- 45
- 21396489
- lon protease homolog, mitochondrial
- precursor [Homo sapiens]
- 46
- 148277071
- thioredoxin reductase 1, cytoplasmic
- isoform 3 [Homo sapiens]
- 47
- 148596949
- nucleolar and coiled-body phosphoprotein 1
- [Homo sapiens]
- 48
- 4504425
- high mobility group protein B1
- [Homo sapiens]
- 49
- 148491070
- CTP synthase 1 [Homo sapiens]
184 more elements
Dependencies are inferred from the claim text.