US 2014/0349276 A1 · SIGNAL PROPAGATION BIOMOLECULES, DEVICES AND METHODS

Abstract

This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

Claims15

Dependent claims

A structured polynucleotide comprising:

a first domain that acts as a toehold for an input DNA logic gate to initiate binding to a structured chimeric substrate (SCS) biomolecule;
a second domain that acts as a substrate recognition sequence for an upstream DNA logic gate;
a third domain that acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate;
a fourth domain that acts as an effector sequence to alter the state of the output logic gate;
and
a fifth domain that acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

3 more elements

Dependencies are inferred from the claim text.

Signal propagation biomolecules, devices and methods

Life of this patent

Signal propagation biomolecules, devices and methods

Life of this patent

Abstract

Claims15