Use of a flavanol glycoside for suppressing activation of stellate cells
AssigneeHong Kong Baptist University
InventorsZhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
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Abstract
A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
Claims19
A method for suppressing activation of stellate cells present in an internal organ of a subject by administering to the subject a composition comprising a therapeutically effective amount of:
- an extract from a fern belonging to the Thelypteridaceae family;
- a flavanol glycoside which comprises a compound of formula (1):
- wherein R1, R2, R4, R6, R7, R8, R9, and R10 are each independently hydrogen, hydroxy or C1-6 alkoxy whereas R3 and R5 are each independently C1-6 alkyl;
- and
- derivatives or chemical variants thereof;
- or a mixture of said extract, compound, derivatives and/or chemical variants thereof.
A method for preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases by administering to a subject in needs thereof a composition comprising a therapeutically effective amount of:
- an extract from a fern belonging to the Thelypteridaceae family;
- a flavanol glycoside which comprises a compound of formula (1):
- wherein R1, R2, R4, R6, R7, R8, R9, and R10 are each independently hydrogen, hydroxy or C1-6 alkoxy whereas R3 and R5 are each independently C1-6 alkyl;
- and
- derivatives or chemical variants thereof;
- or a mixture of said extract, compound, derivatives and/or chemical variants thereof.
A method of extracting and isolating a flavanol glycoside from Pronephrium penangianum comprising:
- extracting a Pronephrium penangianum sample with a first solvent to form one or more first extracts;
- treating the one or more first extracts to form a crude extract;
- extracting the crude extract with a second solvent to form a second extract;
- separating the second extract by using a first column chromatography to form at least one fraction;
- separating the at least one fraction by using a second column chromatography to form at least one subfraction;
- purifying the at least one subfraction to yield the flavanol glycoside.
Dependencies are inferred from the claim text.