Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis
AssigneePiramal Enterprises Limited
InventorsSomesh Sharma, Alan Hatfield, Shivani Acharya
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Abstract
The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or pharmaceutically acceptable salts, solvates, stereoisomers or diastereoisomers thereof or pharmaceutical compositions containing the compounds of Formula (I) for use in the prevention and/or treatment of oral mucositis caused by cancer therapy such as radiation therapy.
Claims19
1-19. (canceled)
A method for the prevention, treatment or reduction in severity of oral mucositis comprising administering to a subject undergoing cancer therapy, a therapeutically effective amount of a compound of Formula (I),
- wherein Ar is a phenyl group substituted by 1 or 2 identical or different substituents selected from chlorine, bromine, fluorine, iodine, C1-C4-alkyl, or trifluoromethyl;
- or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof.
A method for the prevention, treatment or reduction in severity of oral mucositis comprising administering to a subject undergoing cancer therapy, a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of compound of Formula (I),
- wherein Ar is a phenyl group substituted by 1 or 2 identical or different substituents selected from chlorine, bromine, fluorine, iodine, C1-C4-alkyl, or trifluoromethyl;
- or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.