Gastroretentive controlled release vehicles that include ethylene copolymers, ethyl celluloses, and/or thermoplastic polyurethanes
AssigneeCelanese EVA Performance Polymers LLC
InventorsJose Reyes, Kenneth Anderson, Dale Zevotek, Nathan Reuter, J. Gregory Little, Jeffrey Haley, Vassilios Galiatsatos
Life of this patent
Estimating the term…
Abstract
Gastroretentive controlled release vehicles may, in some embodiments, (1) comprise a polymeric matrix and agents for the treatment, prevention, and/or mitigation of a disease and/or side effect thereof and (2) have both gastroretentive properties and controlled release properties. Preferrably, the polymeric matrix may comprise ethylene copolymers, ethyl celluloses, and/or thermoplastic polyurethanes that may optionally be partially crosslinked.
Claims21
1-78. (canceled)
A gastroretentive control release vehicle comprising:
- a polymeric matrix comprising at least one selected from the group consisting of an ethylene copolymer, an ethyl cellulose, a thermoplastic polyurethane, any partially crosslinked polymer thereof, and any combination thereof;
- an agent associated with the polymer matrix, the agent being for the treatment, prevention, and/or mitigation of a disease or a side effect thereof;
- and
- a gastroretentive additive comprising at least one selected from the group consisting of a swellable polymer, an effervescent material, a physical blowing compound, a bioadhesive, a gastroretentive compound, and any combination thereof.
A gastroretentive control release vehicle comprising:
- a polymeric matrix comprising at least one selected from the group consisting of an ethylene copolymer, an ethyl cellulose, a thermoplastic polyurethane, any partially crosslinked polymer thereof, and any combination thereof;
- an agent associated with the polymer matrix, the agent being for the treatment, prevention, and/or mitigation of a disease or a side effect thereof;
- and
- wherein the density of the gastroretentive control release vehicle ranges from about 0.1 g/cm3 to about 0.97 g/cm3.
A method comprising:
- providing a polymer melt comprising at least one selected from the group consisting of an ethylene copolymer, an ethyl cellulose, a thermoplastic polyurethane, any partially crosslinked polymer thereof, and any combination thereof;
- extruding the polymer melt through an extruder;
- introducing an agent into the polymer melt;
- and
- forming a gastroretentive controlled release vehicle having a density of the gastroretentive control release vehicle ranges from about 0.1 g/cm3 to about 0.97 g/cm3.
Dependencies are inferred from the claim text.