Immediate release formulations and dosage forms of gamma-hydroxybutyrate
AssigneeJazz Pharmaceuticals, Inc.
InventorsAndrea Marie Rourke, Maura Patricia Murphy, James Frederick Pfeiffer, Clark Patrick Allphin, Alya Kahn McGinlay
Life of this patent
Estimating the term…
Abstract
The present invention provides a solid immediate release dosage form adapted for oral administration of GHB. The solid immediate release dosage form includes an immediate release formulation comprising a relatively high weight-percentage of GHB with a bioavailability similar to that of a liquid GHB dosage form.
Claims38
An immediate release dosage form for oral delivery of GHB, the immediate release dosage form comprising:
- an immediate release formulation comprising a pharmaceutically acceptable salt of GHB in an amount of at least 70% by weight of the immediate release formulation;
- and
- wherein the immediate release dosage form releases at least 90% of the GHB salt contained therein within a period of less than one hour after administration.
An immediate release formulation for oral delivery of GHB, the immediate release formulation comprising:
- GHB in an amount of about 90-98% by weight;
- at least one binder in an amount of about 1-5% by weight;
- at least one lubricant in an amount of about 1-5% by weight;
- and
- wherein the immediate release formulation releases at least 90% of the GHB contained therein within a period of less than one hour after administration.
-35. (canceled)
A method for treating an individual afflicted with a condition treatable with GHB, the method comprising:
- administering an immediate release formulation for oral delivery of sodium oxybate, the immediate release formulation comprising:
- sodium oxybate in an amount of about 90-98% by weight;
- at least one binder in an amount of about 1-5% by weight;
- at least one lubricant in an amount of about 1-5% by weight;
- and
- wherein the immediate release dosage form releases at least 90% of the GHB contained therein within a period of less than one hour after administration.
-51. (canceled)
Dependencies are inferred from the claim text.