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US 2014/0348915 A9Published application
Oral Dosage Forms of Methyl Hydrogen Fumarate and Prodrugs Thereof
AssigneeXenoPort, Inc.
InventorsSami Karaborni, Laura Elizabeth Bauer, Chen Mao, Ching Wah Chong, David J. Wustrow, Peter A. Virsik
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Abstract
Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed.
Claims29
An oral pharmaceutical tablet, comprising:
- (A) a tablet core comprising (i) a compound selected from (a) methyl hydrogen fumarate (MHF), (b) a prodrug of MHF, (c) pharmaceutically acceptable salts of (a) or (b), and (d) combinations of any of the foregoing, and (ii) one or more core tableting excipients;
- and
- (B) a compressed coating layer surrounding said tablet core, the coating layer comprising a material that is either (i) a proton-donating acidic material having a pKa of greater than 8, (ii) a proton-accepting basic material having a pKa of less than 2, (iii) a natural gum or polysaccharide, (iv) a neutral polymer salt, or (v) a lipid,
- the coating layer releasing no more than 20% of the compound over a period of 2 hours after the tablet is placed in an aqueous solution free of the compound.
1 more element
Dependencies are inferred from the claim text.