Method for reducing blood pressure using inhibitors of plasma kallikrein

A method of reducing blood pressure in a subject in need thereof, said method comprising administering to said subject an effective amount of a compound having the formula II:

• wherein
• the subscript m is an integer of from 0 to 5;
• the subscript n is an integer of from 0 to 4;
• the subscript q is an integer of from 0 to 1;
• L is a linking group selected from the group consisting of a bond, CH2, and SO2;
• each of Rh and Rc is independently selected from the group consisting of cycloalkyl, (C1-C8)haloalkyl, halogen, —OH, —OR2, —OSi(R2)3, —OC(O)O—R2, —OC(O)R2, —OC(O)NHR2, —OC(O)N(R2)2, —SH, —SR2, —S(O)R2, —S(O)2R2, —SO2NH2, —S(O)2NHR2, —S(O)2N(R2)2, —NHS(O)2R2, —NR2S(O)2R2, —C(O)NH2, —C(O)NHR2, —C(O)N(R2)2, —C(O)R2, —C(O)H, —C(═S)R2, —NHC(O)R2, —NR2C(O)R2, —NHC(O)NH2, —NR2C(O)NH2, —NR2C(O)NHR2, —NHC(O)NHR2, —NR2C(O)N(R2)2, —NHC(O)N(R2)2, —CO2H, —CO2R2, —NHCO2R2, —NR2CO2R2, —R2, —CN, —NO2, —NH2, —NHR2, —N(R2)2, —NR2S(O)NH2, —NR2S(O)2NHR2, —NH2C(═NR2)NH2, —N═C(NH2)NH2, —C(═NR2)NH2, —NH—OH, —NR2—OH, —NR2—OR2, —N═C═O, —N═C═S, —Si(R2)3, —NH—NHR2, —NHC(O)NHNH2, NO, —N═C≡NR2, and —S—CN, wherein each R2 is independently alkyl, aryl, or arylalkyl;
• when q is 0, Z is a member selected from the group consisting of O, S, and NRd, wherein Rd is H or C1-C8 alkyl;
• when q is 1, Z is N;
• or
• a pharmaceutically acceptable salt thereof.