Compounds and Method for Modulating Inflammatory Reactions
AssigneeUniversite Laval
InventorsPhilippe Tessier, Carle Ryckman, Pascal Rouleau, Karen Vandal
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Abstract
The present invention relates to compounds and methods for modulating, reducing or inhibiting, inflammatory reactions in a patient. Particularly, inflammatory reactions that are targeted by the present invention are cell migration, secretion of toxic products and proteolysis at a site of inflammation. Reduction of inflammation manifestations and reactions occurs by using an anti-S100 polynucleotide or polypeptide inhibitor or antagonist, which is essentially targeted against S100A8, S100A9 or S100A12, alone or in combination with other inhibitors of chemokines or immune modulating products.
Claims5
A method for the treatment of an inflammatory reaction selected from Crohn's disease and ulcerative colitis in a human suffering therefrom comprising administering to said human an inflammatory reaction treatment effective amount of an antibody or a fragment thereof directed against S100A9.
Dependencies are inferred from the claim text.