Anti-gitr antibodies
AssigneeMerck Sharp & Dohme Corp.
InventorsXiao Min Schebye, Grigori P. Ermakov, Douglas J. Hodges, Leonard G. Presta
Life of this patent
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Abstract
Antibodies to human GITR are provided, as well as uses thereof, e.g., in treatment of proliferative and immune disorders.
Claims22
A binding compound that binds to human GITR comprising:
- a) an antibody light chain variable domain, or antigen binding fragment thereof, having three CDR sequences selected from the group consisting of SEQ ID NOs:
- 59-88 and
- b) an antibody heavy chain variable domain, or antigen binding fragment thereof, having three CDR sequences selected from the group consisting of SEQ ID NOs:
- 23-55.
An antibody or antigen binding fragment thereof, produced by a hybridoma deposited at the American Type Culture Collection (ATCC), wherein the hybridoma is selected from the group consisting of PTA-9889, PTA-9890, PTA-9891, PTA-9892, PTA-9893, PTA-10286, PTA-10287, PTA-10288, PTA-10289, PTA-10290, and PTA-10291.
An antibody or antigen binding fragment that binds to human GITR protein, wherein the antibody or antigen binging fragment recognizes an epitope spanning module 3 and module 4 of human GITR protein (SEQ ID NO:
- 89).
Dependencies are inferred from the claim text.