Method of treating and reducing the risk of acute myelogenous leukemia
AssigneeMemorial Sloan-Ketting Cancer Center
InventorsStephen D. Nimer, Lan Wang
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Abstract
The present invention relates to methods and compositions for treating and reducing the risk of Acute Myelogenous Leukemia (AML). In particular, the invention provides methods for identifying novel treatments for AML based on reproducible and detectable changes in AML1-ETO acetylation. The present invention further provides methods of using these treatments.
Claims21
A method of identifying agents for treating or reducing risk for acute myelogenous leukemia comprising:
- providing a system in which AML1-ETO acetylation level is determinable;
- contacting the system with a test agent;
- determining AML1-ETO acetylation level when the test agent is present;
- comparing the determined AML1-ETO acetylation level with a reference AML1-ETO acetylation level so that any difference between the reference level and the determined level is detected;
- and
- characterizing the test agent's usefulness in treating or reducing risk for acute myelogenous leukemia based on the detected difference.
Methods of treating or reducing risk for acute myelogenous leukemia comprising administering to a subject one or more AML1-ETO acetylation inhibitors.
A method of identifying agents for treating or reducing risk for acute myelogenous leukemia comprising:
- determining transcription levels of one or more targets of AML1-ETO transcriptional activation contacted to a test agent;
- and
- identifying the test agent as treating or reducing risk for acute myelogenous leukemia if the transcription levels are reduced relative to transcription levels in comparable conditions lacking the test agent.
Methods of treating or reducing risk for acute myelogenous leukemia comprising administering to a subject one or more agents characterized in that transcription levels of one or more targets of AML1-ETO transcriptional activation are lower in the agent's presence as compared with in its absence.
Dependencies are inferred from the claim text.