Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof

A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein

• VD1 is a first variable domain;
• VD2 is a second variable domain;
• C is a constant domain;
• X1 is a linker;
• X2 is an Fc region;
• n is 0 or 1,
• wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding DLL4 and VEGF, wherein:
• (i) the variable domains that form a functional target binding site for DLL4 comprise:
• three CDRs from SEQ ID NO:
• 39 and three CDRs from SEQ ID NO:
• 40;
• and
• (ii) the variable domains that form a functional target binding site for VEGF comprise:
• three CDRs from SEQ ID NO:
• 41 and three CDRs from SEQ ID NO:
• 42,
• three CDRs from SEQ ID NO:
• 43 and three CDRs from SEQ ID NO:
• 44,
• three CDRs from SEQ ID NO:
• 45 and three CDRs from SEQ ID NO:
• 46,
• three CDRs from SEQ ID NO:
• 47 and three CDRs from SEQ ID NO:
• 48,
• three CDRs from SEQ ID NO:
• 49 and three CDRs from SEQ ID NO:
• 50,
• three CDRs from SEQ ID NO:
• 51 and three CDRs from SEQ ID NO:
• 52, or
• three CDRs from SEQ ID NO:
• 53 and three CDRs from SEQ ID NO:
• 54.