Methods of Treating Cancer
AssigneesDana-Farber Cancer Institute, Inc., The Broad Institute, Inc.
InventorsTodd Golub, Ravid Straussman
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Abstract
The present invention provides methods of treating cancer.
Claims21
A method of preventing or reducing chemoresistance in a tumor comprising administering to a subject with cancer a chemotherapeutic agent and a c-MET kinase (MET) inhibitor.
A method of treating a tumor having a B-RAF activating mutation in a subject comprising administering an effective amount of a MET inhibitor to the subject.
A method of diagnosing or determining a predisposition to developing chemoresistance in a tumor comprising determining the level of HGF in expression in the tumor and comparing the level of HGF expression to a control sample, wherein an increase level of HGF expression in the tumor compared to the control indicates chemoresistance or a predisposition to developing chemoresistance in the tumor.
A method of diagnosing or determining a predisposition to developing chemoresistance in a tumor comprising determining the level of MET activation in the tumor and comparing the level of MET activation to a control sample, wherein an increase level of MET activation in the tumor compared to the control indicates chemoresistance or a predisposition to developing chemoresistance in the tumor.
Dependencies are inferred from the claim text.