Biomarkers of kawasaki disease
AssigneeBaylor Research Institute
InventorsVirginia M. Pascual, Zhaohui Xu, Octavio Ramilo, Rolando Cimaz
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Abstract
Biomarkers of Kawasaki Disease (KD) are provided. In certain aspects, methods are provided for detecting KD biomarkers, such as elevated PDGFC expression. Likewise, methods of treating a subject having a biomarker of KD are described.
Claims51
A method for detecting a biomarker of Kawasaki disease (KD) in a subject comprising determining a platelet-derived growth factor C (PDGFC) expression level in a biological sample from a subject suspected of having or at risk for having KD, wherein elevated PDGFC expression relative to a reference level identifies the subject as having a biomarker of KD.
A method for treating a subject with Kawasaki disease (KD) comprising:
- (a) evaluating expression of platelet-derived growth factor C (PDGFC) in the subject;
- and
- (b) administering an anti-KD therapy to the subject if the subject exhibits elevated PDGFC expression relative to a reference level.
A method for treating a subject with Kawasaki disease (KD) comprising:
- (a) administering an anti-KD therapy to the subject;
- (b) evaluating expression of platelet-derived growth factor C (PDGFC) in the subject;
- and
- (c) administering a further anti-KD therapy to the subject if the subject exhibits elevated PDGFC expression relative to a reference level.
A method for treating Kawasaki disease (KD) comprising administering an anti-KD therapy to a subject determined to have elevated platelet-derived growth factor C (PDGFC) expression relative to a reference level.
A tangible computer-readable medium comprising computer-readable code that, when executed by a computer, causes the computer to perform operations comprising:
- a) receiving information corresponding to a level of expression of platelet-derived growth factor C (PDGFC) in a sample from a subject suspected of having or at risk for having KD;
- and
- b) determining a relative level of expression of PDGFC compared to a reference level, wherein elevated PDGFC expression relative to the reference level indicates the presence of a biomarker of KD.
Dependencies are inferred from the claim text.