Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
OwnerOlga De La Rosainventor
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Abstract
The present invention relates to immunomodulatory cells, methods for providing immunomodulatory cells, and therapeutic uses of the cells for the immune modulation of mammals in need thereof.
Claims19
An isolated cell population consisting essentially of ex-vivo generated multiple sclerosis-associated antigen-specific regulatory T-cells expressing one or more of CD62-L, FOXP3 and CTLA4.
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A method for the preparation, expansion and/or generation of antigen-specific immunomodulatory cells which comprises ex-vivo contacting an isolated regulatory T cell population with a mesenchymal stem cell (MSC) population in the presence of one or more multiple sclerosis-associated antigens.
A method for the selection of a cell population comprising:
- i) providing an isolated cell population;
- ii) determining the expression of one or more markers selected from the group consisting of CD62-L, FOXP3 and CTLA4;
- and
- iii) selecting cells positive for at least 1, 2 or 3 of said markers.
A method for treating a subject having multiple sclerosis comprising the steps of:
- i) providing a PBL population;
- ii) contacting said PBLs with a cell population comprising of MSC and/or fibroblast cells in the presence of one or more multiple sclerosis-associated antigens;
- iii) isolating the immunomodulatory cell population;
- and
- iv) administering the immunomodulatory cell population to said subject.
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Dependencies are inferred from the claim text.