Methods to reduce polyposis and colorectal cancer
AssigneeNorth Carolina State University
InventorsTodd Klaenhammer, Mansour Mohamadzadeh
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Abstract
Methods for reducing or inhibiting polyposis or colorectal cancer are provided. The methods comprise administering to a mammal a bacterium modified to decrease the display of lipoteichoic acid on the cell surface. Administration of the recombinant bacterium promotes a desired therapeutic response. The recombinant bacterium may be administered in a single dose or series of doses. Methods find use in treating or preventing a variety of polyp-related disorders, for example, treating or Lynch syndrome, familial adenomatous polyposis, and colorectal cancer.
Claims31
A method for decreasing polyposis in a mammal comprising, administering to a mammal a therapeutically effective amount of a bacterium having been genetically modified to decrease the display of lipoteichoic acid (LTA) on the surface of said bacterium.
A method for inhibiting polyposis in a mammal comprising, administering to a mammal a therapeutically effective amount of a bacterium having been genetically modified to decrease the display of lipoteichoic acid (LTA) on the surface of said bacterium.
Dependencies are inferred from the claim text.