Adeno-associated virus serotype i nucleic acid sequences, vectors and host cells containing same
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M. Wilson, Weidong Xiao
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Abstract
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are methods of delivering genes via AAV-1 derived vectors.
Claims21
1-85. (canceled)
A recombinant virus having an AAV-1 capsid comprising a vp1 protein, a vp2 protein, and a vp3 protein, wherein said vp3 protein has an amino acid sequence of SEQ ID NO:17, wherein said recombinant virus further comprises a heterologous molecule which comprises an AAV 5′ inverted terminal repeat sequence (ITR), a transgene, and an AAV 3′ ITR.
A method for delivering a transgene to a host cell comprising delivery of a recombinant virus to a mammalian subject, wherein said recombinant virus has an AAV-1 capsid comprising a vp1 protein, a vp2 protein, and a vp3 protein, wherein said vp3 protein has an amino acid sequence of SEQ ID NO:17, wherein said recombinant virus further comprises a heterologous molecule which comprises an AAV 5′ inverted terminal repeat sequence (ITR), said transgene, and an AAV 3′ ITR.
Dependencies are inferred from the claim text.