Reverse thermal gels and their use in cell therapy

A method for increasing survival of a transplanted cell in a subject, comprising

• transplanting into a subject a therapeutically effective amount of a cell;
• and
• administering to the subject an effective amount of poly(ethylene glycol)-poly(serinol hexamethylene urethane),
• thereby increasing the survival of the transplanted cell in the subject.

A method of treating a subject with a spinal cord injury, stroke, or a neurodegenerative disorder, comprising

• administering to a subject a therapeutically effective amount of a cell;
• and
• administering to the subject a therapeutically effective amount of a reverse thermal gel composition comprising a triblock copolymer, or a pharmaceutically acceptable salt thereof, having the structure B-A-B in which A is one of a polyurethane or poly(ester urethane) group that comprises one or more pendant active groups, blocked active groups or active agents and B is a hydrophilic block, wherein the composition is a gel at 35° C. to 40° C. and a liquid solution at a lower temperature,
• thereby treating the spinal cord injury, stroke, or the neurodegenerative disorder.