Diagnostic methods
AssigneeColgate-Palmolive Company
InventorsLynette Zaidel, Steven Miller, Guy Carpenter, Gordon Proctor, David Bartlett, Rebecca Moazzez
Life of this patent
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Abstract
Described herein are methods for identifying a mammal having a heightened susceptibility to enamel erosion, together with kits therefor and uses and methods related thereto.
Claims15
A method for identifying a mammal having a heightened susceptibility to enamel erosion, comprising:
- a. obtaining a sample of whole mouth saliva from the oral cavity of the mammal;
- b. measuring the concentration of one or more of the following biomarkers:
- i) mucin 5B;
- ii) carbonic anhydrase 6;
- and
- iii) statherin;
- and
- c. comparing the mucin B concentration;
- the carbonic anhydrase 6 concentration;
- and/or statherin concentration to a control value for each of said biomarkers;
- wherein said control value is the concentration of said biomarker in a whole mouth saliva sample taken from the oral cavity of a mammal not suffering from erosion;
- and
- wherein a lower mucin 5B concentration relative to said control value for mucin 5B indicates a heightened susceptibility to enamel erosion;
- wherein a lower carbonic anhydrase 6 concentration relative to said control value for carbonic anhydrase 6 indicates a heightened susceptibility to enamel erosion;
- and
- wherein a higher statherin concentration relative to a control value for statherin indicates a heightened susceptibility to enamel erosion.
Use of a kit comprising means for measuring concentrations of one or more of mucin 5B, carbonic anhydrase 6, and statherin in a whole mouth saliva sample taken from the oral cavity of a mammal, for diagnosing heightened susceptibility to enamel erosion in a mammal.
Use of antibodies to one or more of mucin 5B, carbonic anhydrase 6, and statherin for diagnosing heightened susceptibility to enamel erosion in a mammal.
Antibodies to one or more of mucin 5B, carbonic anhydrase 6, and statherin, for use in diagnosing heightened susceptibility to enamel erosion in a mammal.
-21. (canceled)
Dependencies are inferred from the claim text.